Zu "2095719-92-7" wurden 2 Artikel gefunden!
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ERK1/2 inhibitor 2
Artikelnummer: TGM-T8472-100mg
Description: ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity. Target: ERK. Smiles: O=C1C=2C(CN1[C@@H](C(N[C@H](CO)C3=CC(OC)=CC(F)=C3)=O)C)=CC=C(C2)C4=NC(NC5CCOCC5)=NC=C4Cl
| Schlagworte: | ASTX-029, ASTX029 |
| Anwendung: | ERK1/2 inhibitor |
| CAS | 2095719-92-7 |
| MW: | 584.04 D |
ab 42,00 €
ASTX029
Artikelnummer: Cay33557-1
ASTX029 is an ERK inhibitor (IC50 = 2.7 nM for ERK2). It is selective for ERK over a panel of 465 kinases. ASTX029 reduces phosphorylation of p90 ribosomal S6 kinase (RSK) in mutant B-RAF-expressing A375 melanoma and mutant K-Ras-expressing HCT116 colorectal cancer cells with IC50 values of 3.3 and 4 nM,...
| Schlagworte: | (alphaR)-6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethy... |
| Anwendung: | ERK inhibitor |
| CAS | 2095719-92-7 |
| MW: | 584 D |
ab 85,00 €
