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NKP-1339
Artikelnummer: TGM-TQ0016-100mg
Description: NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. Target: DNA/RNA Synthesis. Smiles: [Na+].[Cl-][Ru+3]([Cl-])([Cl-])([Cl-])([N]1=CC=2C=CC=CC2N1)[N]3=CC=4C=CC=CC4N3. References: Robert Trondl, et al. NKP-1339, the first...
| Schlagworte: | KP-1339, IT-139 |
| CAS | 197723-00-5 |
| MW: | 502.14 D |
ab 198,00 €
NKP-1339
Artikelnummer: Cay35123-10
NKP-1339 is a ruthenium complex with anticancer activity. It is cytotoxic to HT-29 and SW480 cells (IC50s = 24.46 and 123.3 µM, respectively). NKP-1339 induces mitochondrial apoptosis in SW480 cells. In vivo, NKP-1339 (10.5, 21, and 42 mg/kg) reduces tumor growth in a SaI/N murine fibrosarcoma model.Formal Name:...
| Schlagworte: | KP1339, (OC-6-11)-tetrachlorobis(1H-indazole-kappaN2)-ruthenate(1-), monosodium salt |
| Anwendung: | Ruthenium complex, anticancer agent |
| CAS | 197723-00-5 |
| MW: | 502.1 D |
ab 262,00 €
