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BDA-366
Artikelnummer: TGM-T6778-100mg
Description: BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-apoptotic entity. This compound effectively suppresses lung cancer cell growth[1]....
| Anwendung: | Bcl2-BH4 domain antagonist |
| CAS | 1909226-00-1 |
| MW: | 423.5 D |
ab 46,00 €
BDA-366
Artikelnummer: Cay35420-1
BDA-366 is an antagonist of the BH4 domain of the anti-apoptotic protein Bcl-2 (Ki = 3.3 nM). It is selective for Bcl-2 over Bcl-xL, Mcl-1, A1/Bfl-1, and Bcl-2 lacking the BH4 domain (Kis = >500, >500, >500, and 654.8 nM, respectively) but does bind to BH1-, BH2-, or BH3 domain-deficient Bcl-2 (Kis = 12.4, 7.6, and...
| Schlagworte: | 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-2-oxiranylmethyl]amino]-9,10-anthracenedione |
| Anwendung: | Bcl2-BH4 domain antagonist |
| CAS | 1909226-00-1 |
| MW: | 423.5 D |
ab 49,00 €
