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AMG319
Artikelnummer: TGM-T6757-100mg
Description: AMG319 is a potent and selective PI3Kdelta inhibitor with an IC50 of 18 nM and exhibits >47-fold selectivity over other PI3Ks. [Phase 2]. Target: PI3K. Smiles: C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ccc(F)cc2nc1-c1ccccn1. References: Cushing TD, et al. J Med Chem. 2015, 58(1), 480-511.
| Anwendung: | PI3K delta inhibitor |
| CAS | 1608125-21-8 |
| MW: | 385.4 D |
ab 42,00 €
AMG 319
Artikelnummer: Cay17383-5
AMG 319 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform delta (PI3Kdelta, IC50 = 18 nM) that less effectively targets the alpha, beta, and gamma isoforms (IC50s = 33, 2.7, and 0.85 µM, respectively). It blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation...
| Schlagworte: | 7-fluoro-alphaS-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine |
| Anwendung: | PI3K delta inhibitor |
| CAS | 1608125-21-8 |
| MW: | 385.4 D |
ab 44,00 €
