Zu "1446711-81-4" wurden 2 Artikel gefunden!
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Acoramidis
Artikelnummer: Cay41522-10
Acoramidis is a kinetic stabilizer of transthyretin (TTR). It selectively binds to wild-type TTR and TTRV122I with negative cooperativity (Kd1s = 4.8 and 6.2 nM, respectively, Kd2s = 314 and 139 nM, respectively) over COX-1, COX-2, and the thyroid hormone nuclear receptor (IC50s = >10 µM for all). Acoramidis...
| Schlagworte: | AG-10, 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluoro-benzoic acid |
| Anwendung: | TTR kinetic stabilizer |
| CAS | 1446711-81-4 |
| MW: | 292.3 D |
ab 308,00 €
AG-10
Artikelnummer: TGM-T9447-100mg
Description: AG-10 (Acoramidis) is an orally active and selective kinetic stabilizer of TTR (transthyretin). AG-10 exhibits activity for WT and V122I-TTR. AG-10 is used in the study of transthyretin amyloidosis. Target: Others. Smiles: O(CCCC=1C(C)=NNC1C)C2=CC(C(O)=O)=CC=C2F. References: Sravan C Penchala, et al....
| Schlagworte: | Acoramidis |
| Anwendung: | Targets transthyretin (TTR) |
| CAS | 1446711-81-4 |
| MW: | 292.31 D |
ab 100,00 €
