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CCT244747
Artikelnummer: TGM-T14904-2mg
Description: CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM). Target: Chk. Smiles: COc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1-c1cnn(C)c1. References: Lainchbury M, et al. Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally...
| Anwendung: | Chk1 inhibitor |
| CAS | 1404095-34-6 |
| MW: | 408.46 D |
75,00 €
CCT244747
Artikelnummer: SYN-1216-M001
Solid. Soluble in DMSO. CCT244747 is a novel, potent, highly selective, orally active, ATP competitive CHK1 inhibitor. CCT244747 can inhibit cellular CHK1 activity with an IC50 of 29-170nM. In multiple tumour cell models, this has the effect of significantly enhancing the cytotoxicity of several anticancer drugs...
| Schlagworte: | (R)-3-((1-(Dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonit... |
| Anwendung: | Potent, highly selective CHK1 inhibitor |
| CAS | 1404095-34-6 |
| MW: | 408,5 D |
ab 139,00 €
CCT244747
Artikelnummer: Cay25666-1
CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1, IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 µM. CCT244747 reverses cell cycle arrest at the G2/M phase induced...
| Schlagworte: | 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonit... |
| Anwendung: | Chk1 inhibitor |
| CAS | 1404095-34-6 |
| MW: | 408.5 D |
ab 96,00 €
