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SI-113
Artikelnummer: TGM-T9589-100mg
Description: SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades. Target: SGK. Smiles: C(=CC1=CC=CC=C1)N2C=3C(=C(NCCC4=CC=CC=C4)N=C(NCCO)N3)C=N2. References: Matteoni S, et al. The kinase inhibitor SI113 induces autophagy and...
| Anwendung: | SGK1 inhibitor |
| CAS | 1392816-46-4 |
| MW: | 400.48 D |
ab 40,00 €
SI-113
Artikelnummer: Cay37384-1
SI-113 is a serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 = 600 nM). It is selective for SGK1 over c-Src and Abl kinases at 12.5 µM. SI-113 (12.5 µM) is cytotoxic to MCF-7 breast cancer, A172 glioblastoma multiforme, and RKO colorectal adenocarcinoma cell lines. In vivo, SI-113, in combination with...
| Schlagworte: | 2-[[1-(2-phenylethenyl)-4-[(2-phenylethyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-ethanol |
| Anwendung: | SGK1 inhibitor |
| CAS | 1392816-46-4 |
| MW: | 400.5 D |
ab 41,00 €
