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CB-1158-analog
Artikelnummer: TGM-T70928-100mg
Description: CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent...
| Anwendung: | Arginase inhibitor |
| CAS | 1345810-21-0 |
| MW: | 417.14 D |
ab 1.671,00 €
CB-1158
Artikelnummer: Cay27297-1
CB-1158 is an inhibitor of arginase I and II (IC50s = 0.086 and 0.296 µM for the human enzymes, respectively). It is selective for arginase I and II over neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS, IC50s = >50 µM for all). CB-1158 reverses inhibition of T cell...
| Schlagworte: | INCB 01158, Numidargistat, alpha-amino-alpha-(4-boronobutyl)-1-[(2,4-dichlorophenyl)methyl]-4-piperidineacetic acid |
| Anwendung: | Arginase inhibitor |
| CAS | 1345810-21-0 |
| MW: | 417.1 D |
ab 87,00 €
