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LMT-28
Artikelnummer: TGM-T15769-100mg
Description: LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2. Target: IL Receptor. Smiles: CCCCCC(=C)[C@@H](O)[C@H](C)C(=O)N1[C@H](COC1=O)C(C)C. References: Hong SS, et al. A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor beta Subunit,...
| Anwendung: | gp130 (CD130)-IL6/IL6Ralpha protein-protein interaction inhibitor |
| CAS | 1239600-18-0 |
| MW: | 311.42 D |
ab 31,00 €
LMT-28
Artikelnummer: Cay40837-10
LMT-28 is an inhibitor of the protein-protein interaction between glycoprotein 130 (gp130) and the IL-6-bound form of IL-6 receptor subunit alpha (IL-6Ralpha). It binds to gp130 (Kd = 7.4 µM) and selectively inhibits IL-6-induced STAT3 phosphorylation over leukemia inhibitor factor- or phorbol 12-myristate...
| Schlagworte: | (4S)3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-2-oxazolidinone |
| Anwendung: | gp130 (CD130)-IL6/IL6Ralpha protein-protein interaction inhibitor |
| CAS | 1239600-18-0 |
| MW: | 311.4 D |
ab 92,00 €
