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AZD 2461
Artikelnummer: Cay16876-1
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. AZD 2461 is a PARP inhibitor (IC50 = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter. It was developed to overcome the...
| Schlagworte: | 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone |
| Anwendung: | PARP inhibitor |
| CAS | 1174043-16-3 |
| MW: | 395.4 D |
ab 61,00 €
AZD2461
Artikelnummer: LKT-A9612.25
AZD2461 is a novel anticancer treatment currently in clinical trials. This compound acts as a poly(ADP)ribose polymerase-1 (PARP1) inhibitor, potentially beneficial in homologous recombination-deficient tumors such as BRCA1-associated cancers. Unlike most PARP inhibitors, AZD2461 is not a substrate for...
| Anwendung: | PARP1 inhibitor |
| CAS | 1174043-16-3 |
| MW: | 395.43 D |
ab 225,00 €
AZD-2461
Artikelnummer: TGM-T2484-100mg
Description: AZD2461 is a novel PARP inhibitor. Target: PARP. Smiles: COC1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F. References: Jaspers JE, et al. Cancer Discov, 2013, 3(1), 68-81.
| Anwendung: | PARP inhibitor |
| CAS | 1174043-16-3 |
| MW: | 395.43 D |
ab 33,00 €
