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Edicotinib
Artikelnummer: TGM-T15199-100mg
Description: Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the potential for Alzheimer's disease and rheumatoid arthritis treatment. Target: FLT,...
| Schlagworte: | JNJ-527, JNJ-40346527 |
| Anwendung: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 1142363-52-7 |
| MW: | 461.6 D |
ab 63,00 €
Edicotinib
Artikelnummer: Cay33347-1
Edicotinib is an inhibitor of colony stimulating factor 1 receptor (CSF1R, IC50 = 3.2 nM). It is selective for CSF1R over KIT and FMS-related tyrosine kinase 3 (FLT3, IC50s = 20 and 190 nM, respectively). Edicotinib (0.1-1,000 nM) reduces CSF1-induced phosphorylation of CSF1R and ERK1/2 in N13 microglia. It reduces...
| Schlagworte: | JNJ-40346527, JNJ-527,... |
| Anwendung: | CSF1R inhibitor |
| CAS | 1142363-52-7 |
| MW: | 461.6 D |
ab 67,00 €
