Anti-EGFR-Anti-RNF43 AbTAC Kit

The Anti-EGFR-Anti-RNF43 AbTAC Kit is designed for the targeted degradation of EGFR (epidermal growth factor receptor) induced by Anti-EGFR-Anti-RNF43 AbTAC (Antibody-based Targeted Protein Degradation) (#102492) in cancer cell lines expressing both EGFR and RNF43. Anti-EGFR-Anti-RNF43 AbTAC harnesses the synergistic effects of RNF43, a transmembrane E3 ubiquitin ligase known for its role in protein degradation, to selectively degrade EGFR in cancer cells, making it a promising therapeutic candidate for EGFR-driven cancers. This kit contains enough Anti-EGFR-Anti-RNF43 AbTAC, control antibody and Bafilomycin A1 for 10 AbTAC-mediated protein degradation tests in a 6-well plate or 20 tests in a 12-well plate using the HTC 116 cell line. Further downscaling beyond a 12-well plate is not recommended, and other cell lines may require optimization.