TNF alpha (TNFSF2), equine recombinant (reqTNFalpha)

Produced in Yeast. Amino acid sequence: LRSSSRTPSD KPVAHVVANP QAEGQLQWLS GRANALLANG VKLTDNQLVV PLDGLYLIYS QVLFKGQGCP STHVLLTHTI SRLAVSYPSK VNLLSAIKSP CHTESPEQAE AKPWYEPIYL GGVFQLEKGD QLSAEINQPN YLDFAESGQV YFGIIAL (157). Protein function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. [The UniProt Consortium]