Recombinant Human DES (1-3) IGF-1

Human Des(1-3)Insulin-like Growth Factor-I (IGF-I) is a 67 amino acid analog of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu. Human Des(1-3)IGF-I is more potent than IGF-I in vitro and in vivo. This increased potency is due to reduced binding of human Des(1-3)IGF-I to most of the IGF binding proteins which normally inhibit the biological actions of IGF-I. Human Des(1-3)IGF-I binds to the Type 1 IGF receptor with similar affinity to full length IGF-I.