Noggin, active human recombinant protein

Human Noggin, also known as symphalangism 1 (SYM1) or synostoses (multiple) syndrome 1 (SYNS1), GenBank Accession No. NM_005450, amino-acids 28-232(end), disulfide-linked homodimer, produced in human 293 cells. MW approx. 28kDa (monomer). Endotoxin Level is <1 EU/µg. Biological Activity was measured by Noggin's ability to inhibit BMP-4-induced alkaline phosphatase production by C2C12 mouse myoblast cells. The ED50 is < 20 ng/ml in the presence of 30 ng/ml of human BMP-4.