M-CSF (human), animal free recombinant

Product Description: M-CSF, a potent hematopoietic factor, is generated by a variety of cells such as lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. It serves as a crucial regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their progenitor cells. Notably, M-CSF plays significant roles in modulating dermal thickness and fertility. Clinically, it finds use in treating infections, malignancies, and atherosclerosis, aiding hematopoietic recovery post bone marrow transplantation. While Human M-CSF is reactive in murine systems, the murine molecule lacks activity on Human cells. Recombinant Human M-CSF is a homodimeric protein weighing 36.8 kDa, composed of two 159 amino acid polypeptide subunits. . Amino acid sequence: MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS. Endotoxin concentration: <0.1 EU/µg. Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is = 1.0 ng/ml, corresponding to a specific activity of > 1 x 10^6 units/mg. Contains no preservative. Protein function: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. [The UniProt Consortium]