IL-4 (human):Fc (human) (rec.) (non-lytic)

IL-4 (human):Fc (human) (rec.) (non-lytic)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
CHI-HF-22004-C010 10 µg - -

3 - 9 Werktage*

248,00 €
CHI-HF-22004-C050 50 µg - -

3 - 9 Werktage*

429,00 €
 
The extracellular domain of human IL-4 (aa 25-153) is fused at the C-terminus to the Fc portion... mehr
Produktinformationen "IL-4 (human):Fc (human) (rec.) (non-lytic)"
The extracellular domain of human IL-4 (aa 25-153) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the IL-4 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.
Schlagworte: IL4, IL-4, BSF-1, Pitrakinra, Binetrakin, Interleukin-4, B-cell stimulatory factor 1, Lymphocyte stimulatory factor 1
Hersteller: Chimerigen Laboratories
Hersteller-Nr: HF-22004

Eigenschaften

Anwendung: Bioassays
Konjugat: No
Wirt: Mouse cells
Spezies-Reaktivität: human
Reinheit: >98%
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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