IL-15 (human), animal-free recombinant

Product Description: IL-15 serves as an immunomodulatory cytokine that triggers the growth of T lymphocytes, sharing numerous traits with IL-2. Its primary effects are directed towards T cells, aiding in their development, longevity, and activation. Moreover, IL-15 plays a crucial role in nurturing and activating natural killer (NK) cells. Elevated IL-15 levels have been associated with conditions such as rheumatoid arthritis, inflammatory bowel disease, and diseases linked to retroviruses like HIV and HTLV-I. In experiments, Human IL-15 has demonstrated biological activity on mouse cells, notably by stimulating the dose-dependent proliferation of mouse CTLL cells. This recombinant protein, consisting of 115 amino acid residues and weighing 12.9 kDa, mirrors these functions. . Amino acid sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS. Endotoxin concentration: <0.1 EU/µg. Activity: Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is = 0.5 ng/ml, corresponding to a specific activity of > 2 x 10^6 units/mg. Contains no preservative. Protein function: Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155). Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770). [The UniProt Consortium]