IL-11, Mouse

Sequence: PGPPAGSPRV SSDPRADLDS AVLLTRSLLA DTRQLAAQMR DKFPADGDHS LDSLPTLAMS AGTLGSLQLP GVLTRLRVDL MSYLRHVQWL RAGGPSLKTL EPELGALQAR LERLLRRLQL LMSRLALPQA APDQPVIPLG PPASAWGSIR AAHAILGGLH LTLDWAVRGL with polyhistidine tag at the N-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262). The interaction with the membrane- bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans- signaling'. [The UniProt Consortium]