IFN gamma (human), animal-free recombinant

Product Description: IFN-gamma, an acid-labile interferon, is produced by CD4 and CD8 T lymphocytes as well as activated NK cells. Its receptors are widespread in immune cells, triggering an increase in class I MHC protein surface expression upon IFN-gamma signaling. This enhancement aids in antigen presentation to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells, B and T lymphocytes involved in antigen recognition, plays a crucial role in regulating the antigen-specific phases of the immune response. Moreover, IFN-gamma stimulates various functions in lymphoid cells, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Notably, Human IFN-gamma is species-specific and exhibits biological activity exclusively in Human and primate cells. Recombinant Human IFN-gamma is a 16.8 kDa protein composed of 144 amino acid residues. . Amino acid sequence: MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ. Endotoxin concentration: <0.1 EU/µg. Activity: The ED50 determined by a cytotoxicity assay using HT-29 cells is = 0.05 ng/ml, corresponding to a specific activity of > 2 x 10^7 units/mg. Contains no preservative. Protein function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. [The UniProt Consortium]