Human IL-1R2, recombinant (C-Fc)

Recombinant Human Interleukin-1 Receptor Type 2/IL-1R-2 is produced by our Mammalian expression system and the target gene encoding Phe14-Glu343 is expressed with a human IgG1 Fc tag at the C-terminus. Protein function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. [The UniProt Consortium]