Fc (human):RANKL, Soluble (mouse, rec.)

Mouse RANKL (amino acids 157-316) is fused to at the N-terminus to the Fc portion of human IgG1. Induces osteoclastogenesis of bone marrow-derived macrophages. Lyophilized. Contains PBS. RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. Important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.