CNTF (human), animal-free recombinant

Product Description: CNTF, initially identified as crucial for the survival of chick ciliary neurons in lab cultures, plays a significant role in supporting various neural cell types' survival. These include primary sensory neurons, motor neurons, basal forebrain neurons, and type 2 astrocytes. CNTF's importance extends across different species, showcasing its conserved nature and cross-species effectiveness. The synthetic form, Recombinant Human CNTF, comprises a 199 amino acid polypeptide (22.8 kDa), devoid of a hydrophobic N-terminal signal required for secretion. . Amino acid sequence: AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM. Endotoxin concentration: <0.1 EU/ug. Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml Contains no preservative. Protein function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. [The UniProt Consortium]