CCL2 Biotinylated (MCP-1), equine recombinant (reqCCL2)

Produced in Yeast. Amino acid sequence: QPDAINSPVT CCYTFTGKKI SSQRLGSYKR VTSSKCPKEA VIFKTILAKE ICADPEQKWV QDAVKQLDKK AQTPKP. Protein function: Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. [The UniProt Consortium]