SLC47A1 PrEST Antigen

Protein function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium), a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. [The UniProt Consortium] Buffer: PBS and 1M Urea, pH 7.4.