SET8 (human recombinant)

Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated. SET8 selectively mono-methylates histone H4 at lysine 20, an event proven to have an important role in chromatin structure and transcriptional activation. SET8 is also a novel regulator of p53, mono-methylating lysine 382 of the tumor suppressor. SET8's ability to suppress p53 transcriptional activity implies that it may play a significant role in tumorigenesis.Synonyms: KMT5a, PR-Set7, SETD8, SET domain-containing (lysine methyltransferase) 8. Purity: >90% estimated by SDS-PAGE. Source: Active recombinant N-terminal hexahistidine-tagged protein purified from E. coli. Amino Acids: 190-352. MW: 21.1 kDa. Formulation: (Request formulation change), 50 mM sodium phosphate, pH 7.2, with 100 mM sodium chloride and 20% glycerol. UniProt Accession #: Q9NQR1.