RNA polymerase II subunit A C-terminal domain phosphatase (Ctdp1), partial, mouse, recombinant

RNA polymerase II subunit A C-terminal domain phosphatase (Ctdp1), partial, mouse, recombinant
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
CSB-EP745884MO.20 20 µg -

10 - 14 Werktage*

364,00 €
CSB-EP745884MO.100 100 µg -

10 - 14 Werktage*

666,00 €
CSB-EP745884MO.1 1 mg -

10 - 14 Werktage*

2.209,00 €
 
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 178-341aa. Protein Length:... mehr
Produktinformationen "RNA polymerase II subunit A C-terminal domain phosphatase (Ctdp1), partial, mouse, recombinant"
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 178-341aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: HRNRKLVLMV DLDQTLIHTT EQHCPQMSNK GIFHFQLGRG EPMLHTRLRP HCKDFLEKIA KLYELHVFTF GSRLYAHTIA GFLDPEKKLF SHRILSRDEC IDPFSKTGNL RNLFPCGDSM VCIIDDREDV WKFAPNLITV KKYVYFPGTG DVNAPPAARE TQAR. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. Reference: "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010). Function: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation (By similarity).
Schlagworte: Fcp1, Ctdp1, EC=3.1.3.16, TFIIF-associating CTD phosphatase, RNA polymerase II subunit A C-terminal domain phosphatase, Recombinant Mouse RNA polymerase II subunit A C-terminal domain phosphatase (Ctdp1), partial
Hersteller: Cusabio
Hersteller-Nr: EP745884MO

Eigenschaften

Anwendung: Activity not tested
Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: mouse
MW: 24 kD
Reinheit: >90% (SDS-PAGE)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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