Recombinant Human GUCA2B Protein

Tag: C-His. Modification: unmodified. Start Site: Tyr31. End Site: Gly110. Coverage: 0.76. Isoelectric Point: 7. Core Sequence: YQGFRVQLES MKKLSDLEAQ WAPSPRLQAQ SLLPAVCHHP ALPQDLQPVC ASQEASSIFK TLRTIANDDC ELCVNVACTG. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 69%, Rat - 68%, Pig - 82%, Cynomolgus monkey - 97%, Protein Function: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport [The Uniprot Consortium]