PPARdelta (human, recombinant)

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family of ligand activated transcription factors that heterodimerize with retinoic acid like receptors, regulating gene expression and differentiation. The PPAR family of nuclear hormone receptors consists of three subtypes encoded by separate genes: PPARalpha, PPARdelta (also referred to as hNUC1, PPARbeta, or FAAR), and PPARgamma. PPARdelta is ubiquitously expressed but is particularly abundant in tissues such as liver, intestine, kidney, abdominal adipose, and skeletal muscle, all of which are involved in lipid metabolism. PPARdelta is a mediator of diverse physiological functions including lipid and cholesterol homeostasis, embryo implantation, and cancer development. Most recently, attention has been focused on the role of PPARdelta in obesity. Cayman's PPARdelta protein is purified from a baculovirus overexpression system. The purity was determined using gel electrophoresis followed by coomassie staining.Synonyms: FAAR, NUC1, Nuclear Hormone Receptor 1, Peroxisome Proliferative Activated Receptor delta, PPARbeta. Purity: >95% estimated by SDS-PAGE. Protein Identity Confirmed by Mass Spec: Yes. Source: Recombinant protein isolated from baculovirus overexpression system in Sf21 cells. Amino Acids: 2-441 (full length). MW: 54 kDa. Formulation: (Request formulation change), A solution in 50 mM of sodium phosphate, pH 7.2, containing 20% glycerol, 100 mM sodium chloride, and 1 mM DTT.