PD-1 (CD279), Fc fusion (Human)

Human secreted programmed cell death 1 (PDCD1)-Fc fusion protein, also known as, PD-1, and SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, expressed in a HEK293 cell expression system. MW = 42.6. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. Protein function: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors. [The UniProt Consortium]