Nanodisc Human ICLN Protein

Nanodisc Human ICLN Protein
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-HDFP535.10 10 µg -

9 - 20 Werktage*

1.486,00 €
 
Protein function: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm... mehr
Produktinformationen "Nanodisc Human ICLN Protein"
Protein function: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. [The UniProt Consortium]
Schlagworte: ClCI, CLCI, I(Cln), CLNS1A, Reticulocyte pICln, Methylosome subunit pICln, Chloride ion current inducer protein, Chloride channel, nucleotide sensitive 1A, Chloride conductance regulatory protein ICln
Hersteller: Assay Genie
Hersteller-Nr: HDFP535

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: human

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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