GLP-1R mFc Chimera, Human

The GLP1R, a GPCR, is found on pancreatic beta cells and brain neurons. It regulates blood sugar by enhancing insulin secretion. In humans, it is encoded by the gene GLP1R on chromosome 6. GLP1R is part of the glucagon receptor GPCR family and comprises an extracellular domain that binds the C-terminal helix of GLP-1 and a transmembrane domain that binds the N-terminal region of GLP-1. The TMD domain contains polar residues that regulate biased signaling, while the transmembrane helical boundaries and extracellular surface trigger biased agonism.