FTO, Recombinant, Mouse (His) (Fat Mass and Obesity-associated Protein, FATSO)

FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse 'fused toes' mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol. Sequence: Mouse FTO (aa2-502) is fused at the N-terminus to a His-tag, expressed in E. coli. Endotoxin: <1EU/ug (LAL test, Lonza), Molecular Weight: ~55kD (SDS-PAGE), Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.