DLL1/Delta1, His, Human

DLL1, a Notch signaling ligand, is significantly overexpressed in ERalpha luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor prognosis in ERalpha luminal breast cancer, but not in other subtypes of breast cancer. In addition, this effect is specific to DLL1, as other Notch ligands (DLL3, JAGGED1, and JAGGED2) do not influence the clinical outcome of ERalpha patients. DLL1-mediated Notch signaling in breast cancer is important for tumor cell proliferation, angiogenesis, and cancer stem cell function.