CD273 [PD-L2] (human):Fc (human) (rec.) (non-lytic)

The extracellular domain of human CD273 [PD-L2] (aa 20-219) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the CD273 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. T cells require a signal induced by the engagement of the T cell receptor and a ?costimulatory? signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 [PD-L2] is one of two ligands for programmed death-1 (PD-1, CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.