Biotinylated Human IL-18 R1/CD218a Protein

Recombinant Biotinylated Human IL-18 R1/CD218a Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ala19-Arg329. Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-gamma production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-gamma production in response to IL-18 stimulation.