ZBTB38 (Vector pENTR223.1, Accession No. BC008901)

Length: 981 Sequence: atgcaggagg agcctttgcc acaggggaat gacccagaac ccagtggaga cagcccactc gggctttgcc aatccgagtg catggagatg agtgaagtgt tcgatgacgc aagtgaccag gattccactg acaaaccgtg gcgcccttac tacaactaca aacccaaaaa gaaatccaga cagttgaaaa aaatgaggaa agtcaactgg aggaaggagc acggaaacag gagcccgagc cataaatgta aatacccagc agaactggat tgcgccgtgg ggaaggctcc tcaggataaa ccctttgagg aagaagaaac taaagagatg cccaagctgc agtgtgaact ctgtgatgga gacaaagcag tgggggctgg aaaccaagga aggccccacc gacatcttac ttctcggcca tatgcctgcg agctctgcgc caagcagttc cagagccctt ccacactcaa aatgcacatg agatgtcaca ccggggagaa gccataccag tgcaagacct gcggacggtg cttttcggtg caaggaaact tacagaaaca tgaacgcatc cacctgggct tgaaggagtt cgtctgtcag tattgcaaca aggcattcac cttgaatgag accctcaaaa tccatgaaag aatccatact ggagaaaagc gttaccactg tcagttctgc tttcagagat ttttgtatct ctccaccaaa aggaatcacg agcagaggca tattcgggag cataatggga agggctatgc ctgcttccag tgccccaaaa tttgcaaaac agctgctgcc cttggaatgc accaaaagaa acacttattc aaaagcccaa gtcagcagga gaaaataggt gacgtgtgcc acgaaaactc aaatcccttg gagaatcaac atttcattgg ttcagaagac aatgaccaaa aggataacat acaaaccggt gtggaaaatg ttgtcctttg Protein function: Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner, represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons. [The UniProt Consortium]