TWIST2 (Vector pUC, Accession No. BC017907)

Length: 483 Sequence: atggaggagg gctccagctc gcccgtgtcc cccgtggaca gcctgggcac cagcgaggag gagctcgaga ggcagcccaa gcgcttcggc cggaagcggc gctacagcaa gaagtcgagc gaagatggca gcccgacccc gggcaagcgc ggcaagaagg gcagccccag cgcgcagtcc ttcgaggagc tgcagagcca gcgcatcctg gccaacgtgc gcgagcgcca gcgcacccag tcgctcaacg aggccttcgc ggcgctgcgc aagatcatcc ccacgctgcc ctctgacaag ctgagcaaga tccagacgct caagctggcc gccaggtaca tagacttcct ctaccaggtc ctgcagagcg acgagatgga caataagatg accagctgca gctacgtggc ccacgagcgc ctcagctacg ccttctccgt gtggcgcatg gagggcgcgt ggtccatgtc cgcctcccac Protein function: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. [The UniProt Consortium]