TP53RK (Vector pUC, Accession No. BC009727)

Length: 762 Sequence: atggcggcgg ccagagctac tacgccggcc gatggcgagg agcccgcccc ggaggctgag gctctggccg cagcccggga gcggagcagc cgcttcttga gcggcctgga gctggtgaag cagggtgccg aggcgcgcgt gttccgtggc cgcttccagg gccgcgcggc ggtgatcaag caccgcttcc ccaagggcta ccggcacccg gcgctggagg cgcggcttgg cagacggcgg acggtgcagg aggcccgggc gctcctccgc tgtcgccgcg ctggaatatc tgccccagtt gtcttttttg tggactatgc ttccaactgc ttatatatgg aagaaattga aggctcagtg actgttcgag attatattca gtccactatg gagactgaaa aaactcccca gggtctctcc aacttagcca agacaattgg gcaggttttg gctcgaatgc acgatgaaga cctcattcat ggtgatctca ccacctccaa catgctcctg aaaccccccc tggaacagct gaacattgtg ctcatagact ttgggctgag tttcatttca gcacttccag aggataaggg agtagacctc tatgtcctgg agaaggcctt cctcagtacc catcccaaca ctgaaactgt gtttgaagcc tttctgaaga gctactccac ctcctccaaa aaggccaggc cagtgctaaa aaaattagat gaagtgcgcc tgagaggaag aaagaggtcc atggttgggt Protein function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). [The UniProt Consortium]