PAOX (Vector pUC, Accession No. BC032778)

Length: 1536 Sequence: atggagtcga ccggcagcgt cggggaggcc ccgggcggac cccgggtgct ggtggtgggc ggcggcatcg cggggctggg cgcggcgcag aggctctgcg gccactccgc cttcccgcac ctgcgggtcc tggaggccac ggcccgcgcc gggggccgca tccgctcgga gcgctgcttc ggtggcgtgg tggaggtggg cgcgcactgg atccatgggc cctcccgggg taaccccgtc ttccagctgg ctgctgagta cgggctgctg ggggagaagg agctgtccca ggagaaccag ctggtggaga ccgggggtca cgtgggcctg ccctccgtga gctacgccag ctccggggcc agcgtgagcc tccagctggt ggcggagatg gcgactctgt tctacggcct gatagaccag acccgggagt tcctgcacgc tgcagagacc ccggtgccca gcgtcgggga gtacctcaag aaggagattg gccagcacgt ggccggctgg acagaggatg aggagaccag gaagctgaag ctggccgtcc tgaactcctt cttcaacctg gaatgctgtg tgagcggcac ccacagcatg gacctggtgg ccctggcacc ctttggggag tataccgtgc tgccggggct ggactgcacc ttttctaagg gctatcaagg actcacaaac tgcatgatgg ccgccctgcc ggaggacact gtagtttttg agaagcctgt gaagaccatc cactggaacg ggtccttcca ggaggcagcc tttcccgggg agacctttcc agtgtcggta gagtgtgagg atggagaccg gttcccggcg caccatgtca tcgtcaccgt gcccttaggt tttcttaggg aacatttgga caccttcttt gaccctcccc tgccggctga gaaggcagaa gcaatcagga agataggctt tgggaccaac aacaaaatct tcctggagtt tgaggagccc ttctgggagc cagactgcca gctgatccag ctggtgtggg aggacacgtc gcccctggag gatgctgccc ctgagctaca ggacgcctgg ttccggaagc tcattggctt tgtggtcctg cctgcctttg cgtctgtcca cgttctctgt gggttcattg ccggacttga gtctgagttc atggagactc tgtcggatga agaagtactt ctgtgtctca cccaagtgct ccggagagtg acaggaaacc cacggctccc cgcgcccaag agcgtcctgc ggtctcgctg gcacagcgcc ccgtacacta gggggtccta cagctacgtg gccgtgggca gtactggggg cgacctggac ctgctggctc agcccctccc tgcagacggc gccggcgccc agctccagat cctgtttgcg ggggaagcca cacatcgcac gttttactcc acgacgcacg gggctctgct gtcgggatgg agggaggccg accgcctcct cagtctgtgg gccccgcagg tgcagcagcc caggccgagg Protein function: Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)- acetylspermidine to putrescine. Substrate specificity: N(1)- acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). [The UniProt Consortium]