NCAPD2 (Vector pUC, Accession No. BC028182)

Length: 4206 Sequence: atggctcccc aaatgtatga gttccatctg ccattatccc cagaggagtt gttgaaaagt ggaggggtga atcagtatgt tgtgcaagag gtactgtcca tcaaacatct tccaccacag cttagagctt ttcaggctgc ctttcgagct caggggcccc tggctatgct gcagcacttt gatactatct acagcatttt gcatcacttt cgaagtatag atcctggcct caaagaagat actctggaat tcctgataaa agtggtatcc cgccactccc aggagcttcc agctatcctg gatgatacaa ctttgagtgg atcagataga aacgcccatc taaatgccct caaaatgaac tgttatgctc tgatacgtct cctggaatcc tttgagacca tggccagcca gacaaacctt gtggacctgg accttggtgg gaagggtaag aaagctcgga ccaaggcagc ccatggcttt gactgggaag aagagaggca accaattctt cagcttttaa cacagctact tcagttggac atccgtcacc tgtggaacca ctcaataatt gaagaagaat ttgtcagttt ggttactggc tgttgctacc gccttctgga gaatcccacc attaatcacc agaagaaccg ccccactcgg gaagccataa cacacctgct tggtgtagcc ttgacccgtt ataaccatat gctcagtgct acagtgaaga tcatccagat gctgcagcac tttgaacacc tggcacctgt actggttgca gccgtgagtc tatgggcaac tgactatgga atgaagagca tagtgggaga gattgtaaga gagattggac aaaagtgtcc ccaagagctg agtcgagacc cttcagggac aaagggcttt gcagcattcc tgacagaact agcagaacgt gtcccagcta tcctgatgtc cagcatgtgc attttgctag atcacctgga tggagaaaat tacatgatgc gtaatgctgt gctggcagcc atggcggaga tggtgctgca ggttctcagt ggcgatcaac tggaagcagc agcccgagac accagagacc agttcttgga tactttacaa gcccatggcc atgatgtcaa ctcctttgtg cggagccgtg ttttgcagct cttcacccga attgtccagc agaaggctct ccccctgaca cgtttccagg cagtggtggc tttagctgtg ggacgtctgg cagacaagtc agtgctagta tgtaaaaatg ccatccagct gctggccagt tttctagcca ataatccttt ctcctgcaag cttagtgatg ctgaccttgc cggaccactg cagaaggaga cccagaaatt acaagagatg agggcccaga ggcgaactgc agcagcttct gcagtgctgg acccagagga ggagtgggaa gccatgctgc cagagttgaa gtctaccctg cagcagcttc tacagcttcc ccagggagag gaggagattc ctgagcaaat tgccaataca gagacaactg aagatgtgaa aggacgcatc tatcaactgc ttgccaaagc tagttacaaa aaggccatca ttctcactcg agaagccaca ggccacttcc aggagtccga acccttcagt catatagacc cagaggagtc agaggagacc aggctcttga atatcttagg acttatcttc aaaggcccag cagcttccac acaagaaaag aatccccggg agtctacagg aaacatggtc acaggacaga ctgtctgtaa aaataaaccc aatatgtcgg atcctgagga atccagggga aatgatgaac tagtgaagca ggagatgctg gtacagtatc tgcaggatgc ctacagcttc tcccggaaga ttacagaggc cattggcata atcagcaaga tgatgtatga aaacacaact acagtggtgc aggaggtgat tgaattcttt gtgatggtct tccaatttgg ggtaccccag gccctgtttg gggtgcgccg tatgctgcct ctcatctggt ctaaggagcc tggtgtccgg gaagccgtgc ttaatgccta ccgccaactc tacctcaacc ccaaagggga ctctgccaga gccaaggccc aggctttgat tcagaatctc tctctgctgc tagtggatgc ctcggttggg accattcagt gtcttgagga aattctctgt gagtttgtgc agaaggatga gttgaaacca gcagtgaccc agctgctgtg ggagcgggcc accgagaagg tcgcctgctg tcctctggag cgctgttcct ctgtcatgct tcttggcatg atggcacgag gaaagccaga aattgtggga agcaatttag acacactggt gagcataggg ctggatgaga agtttccaca ggactacagg ctggcccagc aggtgtgcca tgccattgcc aacatctcgg acaggagaaa gccttctctg ggcaaacgtc accccccctt ccggctgcct caggaacaca ggttgtttga gcgactgcgg gagacagtca caaaaggctt tgtccaccca gacccactct ggatcccatt caaagaggtg gcagtgaccc tcatttacca actggcagag ggccccgaag tgatctgtgc ccagatattg cagggctgtg caaaacaggc cctggagaag ctagaagaga agagaaccag tcaggaggac ccgaaggagt cccccgcaat gctccccact ttcctgttga tgaacctgct gtccctggct ggggatgtgg ctctgcagca gctggtccac ttggagcagg cagtgagtgg agagctctgc cggcgccgag ttctccggga agaacaggag cacaagacca aagatcccaa ggagaagaat acgagctctg agaccaccat ggaggaggag ctggggctgg ttggggcaac agcagatgac acagaggcag aactaatccg tggcatctgc gagatggaac tgttggatgg caaacagaca ctggctgcct ttgttccact cttgcttaaa gtctgtaaca acccaggcct ctatagcaac ccagacctct ctgcagctgc ttcacttgcc cttggcaagt tctgcatgat cagtgccact ttctgcgact cccagcttcg tcttctgttc accatgctgg aaaagtctcc acttcccatt gtccggtcta acctcatggt tgccactggg gatctggcca tccgctttcc caatctggtg gacccctgga ctcctcatct gtatgctcgc ctccgggacc ctgctcagca agtgcggaaa acagcggggc tggtgatgac ccacctgatc ctcaaggaca tggtgaaggt gaaggggcag gtcagcgaga tggcggtgct gctcatcgac cccgagcctc agattgctgc cctggccaag aacttcttca atgagctctc ccacaagggc aacgcaatct ataatctcct tccagatatc atcagccgcc tgtcagaccc cgagctgggg gtggaggaag agcctttcca caccatcatg aaacagctcc tctcctacat caccaaggac aagcagacag agagcctggt ggaaaagctg tgtcagcggt tccgcacatc ccgaactgag cggcagcagc gagacctggc ctactgtgtg tcacagctgc ccctcacaga gcgaggcctc cgtaagatgc ttgacaattt tgactgtttt ggagacaaac tgtcagatga gtccatcttc agtgcttttt tgtcagttgt gggcaagctg cgacgtgggg ccaagcctga gggcaaggct ataatagatg aatttgagca gaagcttcgg gcctgtcata ccagaggttt ggatggaatc aaggagcttg agattggcca agcaggtagc cagagagcgc catcagccaa gaaaccatcc agtggttcta ggtaccagcc tctggcttct acagcctcag acaatgactt tgtcacacca gagccccgcc gtactacccg tcggcatcca aacacccagc agcgagcttc caaaaagaaa cccaaagttg tcttctcaag tgatgagtcc agtgaggaag atctttcagc agagatgaca gaagacgaga cacccaagaa aacaactccc attctcagag catcggctcg caggcacaga Protein function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [The UniProt Consortium]