MICAL2 (Vector pUC, Accession No. BC044577)

Length: 3375 Sequence: atgggggaaa acgaggatga gaagcaggcc caggcggggc aggtttttga gaactttgtc caggcatcca cgtgcaaagg taccctccag gccttcaaca ttctcacacg acacctggac ctagaccctc tggaccacag aaacttttat tccaagctca agtccaaggt gaccacctgg aaagccaaag ccctgtggta caaattggat aagcgtggtt cccacaaaga gtataagcga gggaagtcgt gcacgaacac caagtgtctc atagttgggg gaggaccctg tggcttgcgc actgccattg aacttgccta cctgggagcc aaagtggtcg tggtggagaa gagggactcc ttctcccgga acaacgtgct acacctctgg cctttcacca tccatgacct tcggggcctg ggagccaaga agttctatgg gaagttctgt gctggctcca tcgaccatat cagtattcgc caactacagc tcatcctatt caaggtggcc ctgatgctgg gagttgaaat ccatgtgaat gtggagttcg tgaaggttct agagcctcct gaagatcaag aaaatcaaaa aattggctgg cgggcagaat ttctccctac agaccattct ctgtcggagt ttgagtttga cgtcatcatt ggtgccgatg gccgcaggaa caccctggaa gggttcagaa gaaaagaatt ccgtgggaag ctggcgattg ccatcaccgc caacttcata aacagaaaca gcacagcgga agccaaggtg gaagagatta gtggtgtggc tttcatcttc aatcagaaat tttttcagga ccttaaagaa gaaacaggca tagatcttga gaacattgtt tactacaagg actgcaccca ctattttgta atgacagcca agaagcagag cctgctcgac aaaggtgtca tcattaacga ctacatcgac acagagatgc tgctgtgtgc ggagaacgtg aaccaagaca acctgctatc ctatgcccgg gaagctgcag actttgccac caactaccag ctgccatcct tagactttgc catgaaccac tatgggcagc ctgatgtggc catgtttgac tttacctgca tgtatgcctc agagaacgcg gccctggtgc gggagcggca ggcgcaccag ctgctcgtgg cccttgtggg tgacagcttg cttgagccat tttggcccat gggtacaggc tgtgcccgtg gcttcctggc agcctttgac acggcatgga tggtgaagag ctggaaccag ggcacccctc ccctggagct gctggctgaa agggaaagtc tctaccggct gttacctcag acaaccccgg agaacatcaa caagaacttt gagcagtaca cgttggaccc agggacacgg tacccaaacc tcaactcaca ctgtgtcagg ccccatcagg tgaagcattt gtatatcact aaggagctgg agcactaccc tctcgagaga ctgggctcgg tgaggagatc tgtcaacctc tccaggaagg agtcagatat ccggcccagc aagctcctga cctggtgcca gcagcagaca gagggctacc agcatgtcaa cgtcaccgac ctgaccacat cctggcgcag tgggttggcc ctgtgtgcca tcatccaccg cttccggcct gagctcatca actttgactc tttgaatgaa gatgatgctg tggagaacaa ccagctcgca tttgatgtgg ccgagcgaga gtttgggatc cctccagtga ccacgggcaa agagatggca tctgcccagg agcctgacaa gctcagcatg gtcatgtacc tctccaagtt ctacgagctc ttccggggca ccccactgag gcccgtggat tcttggcgca aaaactatgg agaaaatgct gacctcagct tggccaaatc atccatttct aataactatc tcaacctcac atttccaagg aagaggactc cacgggtgga tggtcaaacc ggagagaatg acatgaacaa acggagacgg aagggcttca ccaacctgga cgagccttca aacttttcca gccgtagctt gggctccaat caagagtgtg ggagcagtaa ggaaggtgga aatcagaaca aagtcaagtc catggcgaat cagctgctgg ccaagtttga ggagagcact cggaacccct cactcatgaa gcaggaacgc cgtgtctcag ggataggtaa gccggtcctg tgctcttcct ccggccctcc tgttcactct tgctgcccca agccggagga ggccacaccc agcccatcac ctcctctgaa aaggcagttc ccctctgtgg tcgtgacggg gcacgtgctc agagagctca agcaagtgtc tgctggcagt gagtgcctga gcagaccttg gagagccaga gccaagtctg acctacagct gggtgggaca gaaaatttcg ctaccctgcc ttctacccgc ccgagggcgc aggctctttc cggggtgctg tggcggctgc agcaagtgga ggaaaagatt ctccagaaga gggctcagaa cttggccaac agggaatttc acacaaagaa cattaaggag aaggcggctc accttgcctc catgtttgga cacggggatt tcccgcagaa taaactactc tctaaaggcc tgtctcatac tcatcctcca tctcctccct ctcgccttcc gtctcctgat ccagctgctt cttcctctcc atcaactgtt gactctgctt ctcctgccag aaaggaaaag aagtcacctt cagggttcca ttttcatccc agccatttga gaacagtgca tcctcagctg acggtaggga aagtgtccag cggaataggg gctgcagctg aagtcctggt caatctgtac atgaatgatc acagacctaa ggcccaggcc acctctccag acctggaatc tatgcgaaag tcatttcccc ttaacctggg aggcagcgac acgtgttact tctgtaagaa acgtgtgtac gtgatggaac ggctgagcgc cgagggccac ttcttccacc gggagtgttt ccgctgcagc atctgtgcca ccaccttgcg cctggccgcc tacacctttg actgcgatga aggcaaattt tactgcaagc ctcacttcat tcactgtaaa accaatagca aacaacggaa gagacgggca gagttgaagc aacaaagaga ggaggaggca acatggcaag agcaggaagc ccctcggaga gacactccca ccgaaagttc ttgcgcagtg gccgccattg gcaccctgga aggcagcccc ccagttcatt tcagccttcc agtgctacac ccacttcttg Protein function: Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A- dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334). [The UniProt Consortium]