MICAL1 (Vector pUC, Accession No. BC042144)

Length: 3204 Sequence: atggcttcac ctacctccac caacccagcg catgcccact ttgagagctt cctgcaggcc cagctgtgcc aggacgtgct gagcagcttc caggagctgt gtggggccct ggggctggaa cccggtgggg ggctgcccca gtaccacaag atcaaggacc agctcaacta ctggagcgcc aagtcactgt ggaccaagct ggacaagcga gcaggccagc ctgtctacca gcagggccgg gcctgcacca gcaccaagtg cctggtggtg ggtgctggac cttgcgggct gcgggtcgct gtggagctgg cgctgctggg ggcccgagtg gtgctggtgg aaaagcgcac caagttctct cgccacaacg tgctccacct ctggcccttc accatccacg acctgcgggc actcggtgct aagaagttct acgggcgctt ctgcaccggc accctggacc acatcagcat caggcagctc cagctgcttc tgctgaaggt agcattgctg ctgggggtgg aaattcactg gggtgtcact ttcactggcc tccagccccc tcctaggaag gggagtggct ggcgtgccca gctccaaccc aacccccctg cccagctggc caactatgaa tttgacgtcc ttatctcggc tgcaggaggt aaattcgtcc ctgaaggctt caaagttcga gaaatgcgag gcaaactggc cattggcatc acagccaact ttgtgaatgg acgcaccgtg gaggagacac aggtgccgga gatcagtggt gtagccagga tctacaacca gagcttcttc cagagccttc tcaaagccac aggcattgat ctggagaaca ttgtgtacta caaggacgac acccactact ttgtgatgac agccaagaag cagtgcctgc tgcggctggg ggtgctgcgc caggactggc cagacaccaa tcggctgctg ggcagtgcca atgtggtgcc cgaggctctg cagcgcttta cccgggcagc tgctgacttt gccacccatg gcaagctcgg gaaactagag tttgcccagg atgcccatgg gcagcctgat gtctctgcct ttgacttcac gagcatgatg cgggcagaga gttctgctcg tgtgcaagag aagcatggcg cccgcctgct gctgggactg gtgggggact gcctggtgga gcccttctgg cccctgggca ctggagtggc acggggcttc ctggcagcct ttgatgcagc ctggatggtg aagcggtggg cagagggcgc tgagtcccta gaggtgttgg ctgagcgtga gagcctgtac cagcttctgt cacagacatc cccagaaaac atgcatcgca atgtggccca gtatgggctg gacccagcca cccgctaccc caacctgaac ctccgggcag tgacccccaa tcaggtacga gacctgtatg atgtgctagc caaggagcct gtgcagagga acaacgacaa gacagataca gggatgccag ccaccgggtc ggcaggcacc caggaggagc tgctacgctg gtgccaggag cagacagctg ggtacccggg agtccacgtc tccgatttgt cttcctcctg ggctgatggg ctagctctgt gtgccctggt gtaccggctg cagcctggcc tgctggaacc ctcagagctg caggggctgg gagctctgga agcaactgct tgggcactaa aggtggcaga gaatgagctg ggcatcacac cggtggtgtc tgcacaggcc gtggtagcag ggagtgaccc actgggcctc attgcctacc tcagccactt ccacagtgcc ttcaagagca tggcccacag cccaggccct gtcagccagg cctccccagg gacctccagt gctgtattat tccttagtaa acttcagagg accctgcagc gatcccgggc caaggaaaat gcagaggatg ctggtggcaa gaagctgcgc ttggagatgg aggccgagac cccaagtact gaggtgccac ctgacccaga gcctggtgta cccctgacac ccccatccca acaccaggag gccggtgctg gggacctgtg tgcactttgt ggggaacacc tctatgtcct ggaacgcctc tgtgtcaacg gccatttctt ccaccggagc tgcttccgct gccatacctg tgaggccaca ctgtggccag gtggctacga gcagcaccca ggagatggac atttctactg cctccagcac ctgccccaga cagaccacaa agcggaaggc agcgatagag gccctgagag tccggagctc cccacaccaa gtgagaatag catgccacca ggcctctcaa ctcccacagc ctcgcaggag ggggccggtc ctgttccaga tcccagccag cccacccgtc ggcagatccg cctctccagc ccggagcgcc agcggttgtc ctcccttaac cttacccctg acccggaaat ggagcctcca cccaagcctc cccgcagctg ctccgccttg gcccgccacg ccctggagag cagctttgtg ggctggggcc tgccagtcca gagccctcaa gctcttgtgg ccatggagaa ggaggaaaaa gagagtccct tctccagtga agaggaagaa gaagatgtgc ctttggactc agatgtggaa caggccctgc agacctttgc caagacctca ggcaccatga ataactaccc aacatggcgt cggactctgc tgcgccgtgc gaaggaggag gagatgaaga ggttctgcaa ggcccagacc atccaacggc gactaaatga gattgaggct gccttgaggg agctagaggc cgagggcgtg aagctggagc tggccttgag gcgccagagc agttccccag aacagcaaaa gaaactatgg gtaggacagc tgctacagct cgttgacaag aaaaacagcc tggtggctga ggaggccgag ctcatgatca cggtgcagga attgaatctg gaggagaaac agtggcagct ggaccaggag ctacgaggct acatgaaccg ggaagaaaac ctaaagacag ctgctgatcg gcaggctgag gaccaggtcc tgaggaagct ggtggatttg gtcaaccaga gagatgccct catccgcttc caggaggagc gcaggctcag cgagctggcc ttggggacag gggcccaggg Protein function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L, acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. [The UniProt Consortium]