KCNQ2 (Vector pUC, Accession No. BC000699)

Length: 1182 Sequence: atggtgcaga agtcgcgcaa cggcggcgta taccccggcc cgagcgggga gaagaagctg aaggtgggct tcgtggggct ggaccccggc gcgcccgact ccacccggga cggggcgctg ctgatcgccg gctccgaggc ccccaagcgc ggcagcatcc tcagcaaacc tcgcgcgggc ggcgcgggcg ccgggaagcc ccccaagcgc aacgccttct accgcaagct gcagaatttc ctctacaacg tgctggagcg gccgcgcggc tgggcgttca tctaccacgc ctacgtgttc ctcctggttt tctcctgcct cgtgctgtct gtgttttcca ccatcaagga gtatgagaag agctcggagg gggccctcta catcctggaa atcgtgacta tcgtggtgtt tggcgtggag tacttcgtgc ggatctgggc cgcaggctgc tgctgccggt accgtggctg gagggggcgg ctcaagtttg cccggaaacc gttctgtgtg attgacatca tggtgctcat cgcctccatt gcggtgctgg ccgccggctc ccagggcaac gtctttgcca catctgcgct ccggagcctg cgcttcctgc agattctgcg gatgatccgc atggaccggc ggggaggcac ctggaagctg ctgggctctg tggtctatgc ccacagcaag gagctggtca ctgcctggta catcggcttc ctttgtctca tcctggcctc gttcctggtg tacttggcag agaaggggga gaacgaccac tttgacacct acgcggatgc actctggtgg ggcctgatca cgctgaccac cattggctac ggggacaagt acccccagac ctggaacggc aggctccttg cggcaacctt caccctcatc ggtgtctcct tcttcgcgct gcctgcaggc atcttggggt ctgggtttgc cctgaaggtt caggagcagc acaggcagaa gcactttgag aagaggcgga acccggcagc aggcctgatc cagtcggcct ggagattcta cgccaccaac ctctcgcgca cagacctgca ctccacgtgg cagtactacg agcgaacggt caccgtgccc atgtacaggt accgccgccg ggcacctgcc accaagcaac tgtttcattt tttattttcc atttgttctt Protein function: Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873). [The UniProt Consortium]