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Zu "K04927" wurden 22 Artikel gefunden!
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NEU
Artikelnummer: Cay40604-1
Ebio1 is an activator of the voltage-gated potassium channel Kv7.2. It enhances voltage-induced current amplitude in CHO cells expressing recombinant human Kv7.2 when used at a concentration of 10 µM.Formal Name: N-(1,2-dihydro-5-acenaphthylenyl)-4-fluoro-benzamide. CAS Number: 339287-36-4. Molecular Formula:...
Schlagworte: | N-(1,2-dihydro-5-acenaphthylenyl)-4-fluoro-benzamide |
Anwendung: | Kv7.2 activator |
CAS | 339287-36-4 |
MW: | 291.3 D |
ab 66,00 €
Artikelnummer: Cay37294-10
ICA 110381 is an activator of voltage-gated potassium channel Kv7.2. It induces rubidium efflux in an agonist-induced rubidium efflux assay using CHO cells (EC50 = 0.38 µM for the human channel). ICA 110381 also inhibits rubidium efflux from CHO cells expressing Kv7.1 (EC50 = 15 µM for the human channel). It reduces...
Schlagworte: | 4-chloro-N-(6-chloro-3-pyridinyl)-benzamide |
Anwendung: | Kv7.2 (KCNQ2) activator |
CAS | 325457-99-6 |
MW: | 267.1 D |
ab 68,00 €
Artikelnummer: Cay39309-1
Retigabine (Cay-39309) is an analytical reference standard categorized as a positive allosteric modulator (PAM) of KCNQ2-5 (Kv7.2-7.5) potassium ion channels. Formulations containing retigabine have been used in the treatment of partial epilepsies. Retigabine is regulated as a Schedule V compound in the United...
Schlagworte: | D 20443, Ezogabine, N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-carbamic acid, ethyl ester, dihydrochloride |
Anwendung: | Kv7.2-7.5 potassium ion channel positive allosteric modulator (PAM), analytical reference standard |
CAS | 150812-13-8 |
MW: | 376.3 D |
ab 68,00 €
Artikelnummer: Cay21449-1
Retigabine (Cay-21449) is an analytical reference standard categorized as a positive allosteric modulator (PAM) of KCNQ2-5 (Kv7.2-7.5) potassium ion channels. Formulations containing retigabine have been used in the treatment of partial epilepsies. Retigabine is regulated as a Schedule V compound in the United...
Schlagworte: | N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-carbamic acid, ethyl ester |
Anwendung: | Positive allosteric KCNQ2-5 modulator |
CAS | 150812-12-7 |
MW: | 303.3 D |
ab 60,00 €
Artikelnummer: Cay14582-10
The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 µM). It much...
Schlagworte: | 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone, dihydrochloride |
Anwendung: | KCNQ channel blocker |
CAS | 122955-13-9 |
MW: | 449.4 D |
ab 84,00 €
Artikelnummer: Cay19547-1
Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type, Kv7.2/7.3, KCNQ2/3) K+...
Schlagworte: | DuP-996, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one |
Anwendung: | Nootropic, Cognition enhancer |
CAS | 105431-72-9 |
MW: | 391.5 D |
ab 43,00 €
Artikelnummer: Cay15185-10
The KCNQ (Kv7) family of voltage-gated potassium (K+) channels consists of five members, KCNQ1-KCNQ5. KCNQ1-KCNQ5 are critical for setting up the excitation threshold of action potentials. KCNQ1 is expressed mainly in cardiac tissue, peripheral epithelial cells, and smooth muscle cells, while KCNQ2-KCNQ5 are...
Schlagworte: | CID-3111211, N-(2,4,6-trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide |
Anwendung: | KCNQ2 / KCNQ4 activator |
CAS | 489402-47-3 |
MW: | 257.4 D |
ab 92,00 €
Artikelnummer: Cay15191-1
ML-252 is a potent and selective inhibitor of the voltage-gated potassium channel subtype Kv7.2 (IC50 = 69 nM in a patch clamp assay). It is the (S)-enantiomer and is more potent than the (R)-enantiomer and the racemic mixture (IC50s = 944 and 160 nM, respectively). It is selective for Kv7.2 over other Kv channel...
Schlagworte: | (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide, monohydrochloride |
Anwendung: | KCNQ2 inhibitor |
CAS | 2309887-61-2 |
MW: | 344.9 D |
ab 60,00 €
Artikelnummer: Cay22995-10
ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 µM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels...
Schlagworte: | N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-benzamide |
Anwendung: | Kv7 channel activator |
CAS | 582323-16-8 |
MW: | 269.6 D |
ab 127,00 €
Artikelnummer: Cay32849-1
DMP 543 is an inhibitor of the voltage-gated potassium channel Kv7.2 (IC50 = 0.048 µM) and a derivative of linopirdine (Cay-19547). It enhances potassium-induced acetylcholine (ACh) release in rat hippocampal slices (EC50 = 0.83 µM). DMP 543 (1 mg/kg) increases hippocampal extracellular ACh levels in rats.Formal...
Schlagworte: | 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone |
Anwendung: | Kv7.2 inhibitor |
CAS | 160588-45-4 |
MW: | 412.4 D |
ab 43,00 €
Artikelnummer: G-CAB1917.100
Anwendung: | IHC, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 352,00 €
Artikelnummer: ATA-HPA057112.100
Protein function: Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well...
Schlagworte: | Anti-KQT-like 2, Anti-Voltage-gated potassium channel subunit Kv7.2, Anti-Potassium voltage-gated channel subfamily KQT... |
Anwendung: | ICC, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 300,00 €