GPR52 (Vector pUC, Accession No. BC067456)

Length: 1086 Sequence: atgaatgaat ccaggtggac tgaatggagg atcctgaaca tgagcagtgg cattgtgaat gtgtccgagc gtcactcctg cccacttgga tttggccact acagtgtggt ggatgtctgc atcttcgaga cagtggttat tgtgttgctg acatttctga tcattgctgg gaatctaaca gttatctttg tctttcattg tgctccactg ttacatcatt atactaccag ctatttcatt cagacgatgg catatgctga tcttttcgtt ggagttagct gcttggttcc tactctgtca cttctccact actccacagg tgtccacgag tcattgactt gccaggtttt tggatatatc atctcagttc taaaaagtgt ttctatggcg tgtcttgctt gcatcagtgt ggatcgttat cttgcaataa ccaagcctct ttcctacaat caactggtca ccccttgtcg cttgagaatt tgcattattt tgatctggat ctactcctgc ctaattttct tgccttcctt ttttggctgg gggaaacctg gttaccatgg tgacattttt gaatggtgtg ccacgtcttg gctcaccagt gcctatttta ctggctttat tgtttgttta ctttatgctc ctgctgcctt tgttgtctgc ttcacttact tccacatttt caaaatttgc cgtcagcaca ccaaagagat aaatgaccga agagcccgat tccctagtca tgaggtagat tcttccagag agactggaca cagccctgac cgtcgctacg ccatggtttt gtttaggata accagtgtat tttatatgct gtggctcccc tatataattt actttcttct agaaagctcc cgggtcttgg acaatccaac tctgtccttc ttaacaacct ggcttgcaat aagtaatagt ttttgtaact gtgtaatata cagcctctcc aacagcgttt tccggctagg cctccgaaga ctgtctgaga caatgtgcac atcctgtatg tgtgtgaagg atcaggaagc acaagaaccc aaacctagga aacgggctaa ttcttgctcc Protein function: Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). [The UniProt Consortium]