FPR1 (Vector pENTR223.1, Accession No. BC005315)

Length: 1053 Sequence: atggagacaa attcctctct ccccacgaac atctctggag ggacacctgc tgtatctgct ggctatctct tcctggatat catcacttat ctggtatttg cagtcacctt tgtcctcggg gtcctgggca acgggcttgt gatctgggtg gctggattcc ggatgacaca cacagtcacc accatcagtt acctgaacct ggccgtggct gacttctgtt tcacctccac tttgccattc ttcatggtca ggaaggccat gggaggacat tggcctttcg gctggttcct gtgcaaattc gtctttacca tagtggacat caacttgttc ggaagtgtct tcctgatcgc cctcattgct ctggaccgct gtgtttgcgt cctgcatcca gtctggaccc agaaccaccg caccgtgagc ctggccaaga aggtgatcat tgggccctgg gtgatggctc tgctcctcac attgccagtt atcattcgtg tgactacagt acctggtaaa acggggacag tagcctgcac ttttaacttt tcgccctgga ccaacgaccc taaagagagg ataaatgtgg ccgttgccat gttgacggtg agaggcatca tccggttcat cattggcttc agcgcaccca tgtccatcgt tgctgtcagt tatgggctta ttgccaccaa gatccacaag caaggcttga ttaagtccag tcgtccctta cgggtcctct cctttgtcgc agcagccttt tttctctgct ggtccccata tcaggtggtg gcccttatag ccacagtcag aatccgtgag ttattgcaag gcatgtacaa agaaattggt attgcagtgg atgtgacaag tgccctggcc ttcttcaaca gctgcctcaa ccccatgctc tatgtcttca tgggccagga cttccgggag aggctgatcc acgcccttcc cgccagtctg gagagggccc tgaccgagga ctcaacccaa actagtgaca cagctaccaa ttctacttta ccttctgcag aggtggagtt acaggcaaag Protein function: High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G- protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). [The UniProt Consortium]