PRE-084 (hydrochloride)

Sigma receptors are a structurally unique class of intracellular proteins that can be activated by the following agonists: cocaine, morphine/diacetylmorphine, opipramol, PCP, fluvoxamine, methamphetamine, dextromethorphan, and the herbal antidepressant berberin. PRE-084 is a high affinity, sigma receptor agonist, selective for the sigma1 subtype (Kis = 2.2 and 13,091 nM for sigma1 and sigma2 receptors, respectively). It is a potent ligand of the sigma receptor (IC50 = 44 nM) without appreciable affinity for PCP receptors (IC50 > 100,000 nM). PRE-084 has nootropic and antidepressant actions in vivo, as well as antitussive and reinforcing effects.Formal Name: 1-phenyl-2-(4-morpholinyl)ethyl ester-cyclohexanecarboxylic acid, monohydrochloride. CAS Number: 75136-54-8. Molecular Formula: C19H27NO3 . HCl. Formula Weight: 353.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.1 mg/ml, DMSO: 1.1 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml. SMILES: O=C(OCCN1CCOCC1)C2(CCCCC2)C3=CC=CC=C3.Cl. InChi Code: InChI=1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17,/h1,3-4,7-8H,2,5-6,9-16H2,1H. InChi Key: QUJWFJNHTBKCLU-UHFFFAOYSA-N.