Zu "K20719" wurden 49 Artikel gefunden!
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PRE-084 (hydrochloride)
Artikelnummer: Cay9001329-10
Sigma receptors are a structurally unique class of intracellular proteins that can be activated by the following agonists: cocaine, morphine/diacetylmorphine, opipramol, PCP, fluvoxamine, methamphetamine, dextromethorphan, and the herbal antidepressant berberin. PRE-084 is a high affinity, sigma receptor agonist,...
| Schlagworte: | 1-phenyl-2-(4-morpholinyl)ethyl ester-cyclohexanecarboxylic acid, monohydrochloride |
| Anwendung: | Analytical reference standard, selective sigma (sigma1) receptor agonist, nootropic |
| CAS | 75136-54-8 |
| MW: | 353.9 D |
ab 132,00 €
PRE-084 hydrochloride
Artikelnummer: TGM-T3198L-100mg
Description: PRE-084 hydrochloride is a selective agonist of sigma1(IC50:44 nM, in the sigma receptor assay). Target: Sigma receptor. Smiles: Cl.O=C(OCCN1CCOCC1)C1(CCCCC1)c1ccccc1. References: Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron...
| Anwendung: | Selective sigma (sigma1) receptor agonist, nootropic |
| CAS | 75136-54-8 |
| MW: | 353.88 D |
ab 38,00 €
Reduced Haloperidol
Artikelnummer: TGM-T37167-10mg
Description: Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF)...
| Anwendung: | Active metabolite |
| CAS | 34104-67-1 |
| MW: | 377.88 D |
ab 154,00 €
S1RA hydrochloride
Artikelnummer: TGM-T4229-100mg
Description: S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(sigma1R, Ki: 17 nM) antagonist, and has good selectivity against sigma2R (Ki > 1000 nM). Target: Sigma receptor. Smiles: Cl.Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1. References: Díaz JL, et al. Synthesis and biological...
| Schlagworte: | E-52862 hydrochloride |
| Anwendung: | sigma1 receptor antagonist |
| CAS | 1265917-14-3 |
| MW: | 373.87 D |
ab 33,00 €
Blarcamesine hydrochloride
Artikelnummer: TGM-T4111-100mg
Description: Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM). Target: Sigma receptor. Smiles: Cl.CN(C)CC1CCOC1(c1ccccc1)c1ccccc1. References: Villard V, et al. Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (sigma1) ligand...
| Schlagworte: | AE-37 hydrochloride, AVex-73 hydrochloride, Anavex 2-73 |
| Anwendung: | Targets sigma non-opioid intracellular receptor (SIGMAR1) |
| CAS | 195615-84-0 |
| MW: | 317.85 D |
ab 40,00 €
BD1063 dhydrochloride
Artikelnummer: TGM-T7488-100mg
Description: BD1063 dihydrochloride is a potent and selective sigma 1 (sigma1) receptor antagonist (Ki = 9 nM). Target: Sigma receptor. Smiles: Cl.Cl.CN1CCN(CCc2ccc(Cl)c(Cl)c2)CC1. References: Sabino V , Cottone P , Zhao Y , et al. The sigma-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in...
| Schlagworte: | BD1063 |
| Anwendung: | sigma-1 receptor antagonist |
| CAS | 206996-13-6 |
| MW: | 346.12 D |
ab 42,00 €
Blarcamesine
Artikelnummer: TGM-T7780-100mg
Description: Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. Target: AChR. Smiles: C(N(C)C)C1C(OCC1)(C2=CC=CC=C2)C3=CC=CC=C3. References: Matsueda, Gao S , Efferson H , et al. N-terminally LRMK-linked HER-2 peptides, AE-37[J]. 2009.
| Schlagworte: | AE-37, AVex-73 |
| Anwendung: | Targets sigma non-opioid intracellular receptor (SIGMAR1) |
| CAS | 195615-83-9 |
| MW: | 281.39 D |
ab 42,00 €
BD-1047 dihydrobromide
Artikelnummer: TGM-T1740-100mg
Description: BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia. Target: Sigma receptor. Smiles: Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1. References: Skuza G, et al. Pharmacol Rep. 2006...
| Schlagworte: | BD1047.2HBr |
| Anwendung: | sigma receptor antagonist |
| CAS | 138356-21-5 |
| MW: | 437.04 D |
ab 31,00 €
BD 1008 dihydrobromide
Artikelnummer: TGM-T21788-1mg
Description: BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (sigma1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, moderate affinity for sigma2 receptors. Target: Sigma receptor. Smiles: [H]Br.[H]Br.CN(CCC1=CC=C(Cl)C(Cl)=C1)CCN2CCCC2. References:...
| Anwendung: | SIGMAR1 antagonist |
| CAS | 138356-09-9 |
| MW: | 463.08 D |
ab 60,00 €
Cutamesine dihydrochloride
Artikelnummer: TGM-T3597-100mg
Description: Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective sigma1 receptor agonist (IC50: 17.4 nM). It shows selectivity for sigma1 over sigma2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. In a rat model of...
| Schlagworte: | AGY94806 dihydrochloride, SA4503 (dihydrochloride), SA4503 dihydrochloride |
| Anwendung: | sigma-1 receptor agonist |
| CAS | 165377-44-6 |
| MW: | 441.43 D |
ab 38,00 €
Anti-SIGMAR1
Artikelnummer: CSB-PA209031.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SIGMAR1. Antigen Species: Human
| Schlagworte: | Anti-AAG8, Anti-OPRS1, Anti-SR-BP, Anti-SIG-1R, Anti-SIGMAR1, Anti-Sigma1R, Anti-hSigmaR1, Anti-Sigma1-receptor,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-SIGMAR1
Artikelnummer: CSB-PA233715.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SIGMAR1. Antigen Species: Human
| Schlagworte: | Anti-AAG8, Anti-OPRS1, Anti-SR-BP, Anti-SIG-1R, Anti-SIGMAR1, Anti-Sigma1R, Anti-hSigmaR1, Anti-Sigma1-receptor,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €