Hordenine

Hordenine (Cay-21626) is a naturally occurring alkaloid found in a variety of plants, most commonly germinated barley (Hordeum species) from which the name is derived, and is structurally classified as a phenethylamine. It is biosynthesized by the step-wise double methylation of tyramine (Cay-18601). Hordenine binds to and activates the dopamine D2 receptor (Ki = 13 µM) but antagonizes D2 receptor beta-arrestin recruitment. It inhibits tyrosinase activity and expression at concentrations > 50 µM resulting in reduced melanin accumulation in human melanocytes. Hordenine is present in significant amounts in beer and can be measured in serum in the free form, for up to 2 hours, and the glucuronidated form, for up to 6 hours, after beer consumption. This product is intended for research and forensic applications.Formal Name: 4-[2-(dimethylamino)ethyl]-phenol. CAS Number: 539-15-1. Molecular Formula: C10H15NO. Formula Weight: 165.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml. lambdamax: 225, 279 nm. SMILES: OC1=CC=C(CCN(C)C)C=C1. InChi Code: InChI=1S/C10H15NO/c1-11(2)8-7-9-3-5-10(12)6-4-9/h3-6,12H,7-8H2,1-2H3. InChi Key: KUBCEEMXQZUPDQ-UHFFFAOYSA-N.